Association Between Mean Platelet Volume and Severity of Chronic Obstructive Pulmonary Disease (COPD): A Cross-Sectional Study at Khyber Teaching Hospital, Peshawar

Abstract

Background: Across the world, COPD is a leading reason for health problems and higher death rates due to its impact on the lungs and the entire body. Since MPV is involved in platelet activation and inflammation, it might be a good marker for assessing COPD. Still, the results are considered inconclusive. Experts in preventive medicine studied if the presence of MPV would be related to the severity of COPD among patients in Khyber Teaching Hospital. Methods: The study involved COPD patients who were classified according to the GOLD system. The levels of MPV were measured on an automated machine and a chi-square test was used to study the relationship between MPV and the stage of COPD. Results: It was noticeable that COPD severity was strongly related to the grades of MPV in the participants (N = 152). As MPV levels went higher, the patients’ risk of severe or very severe COPD rose. The positive effect was also observed among people aged over 65, among men, among women, among smokers, and also among those who were not smokers. The value of 8.90 was the median MPV, and the IQR was 7.70 to 10.10. A higher number of MPVs were seen in the late stages of the disease. Conclusion: A high MPV level is strongly connected to severe COPD. As a result, MPV may be useful in tracking COPD because it can be measured at a low cost. Based on these findings, platelets may be involved in COPD development and more studies could be done on MPV as a way to predict prognosis. It is important to do both multi-center and longitudinal studies to ensure the results and how MPV is measured are standardized in clinical medicine.

Keywords: Chronic obstructive pulmonary disease COPD, mean platelet volume (MPV), inflammation, biomarker, degree of disease severity, and the GOLD criteria.